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Making biology designable
Anyone can make something that binds. We design binders that work: specific, functional, developable, and aimed at the hardest targets, so the molecules behind better medicines, diagnostics, and tools are engineered on purpose, not discovered by chance.
# Platform
Beyond binding
Known Epitope
Developable
High affinity
Rapid turnaround
In many cases, generating a sequence that sticks to a target is no longer the challenge. Turning that into a binder you can build a programme on is the hard problem, and the one we solve. You provide the target; we deliver wet lab validated binders that work, are specific, functional, and developable.
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Single-shot Kd's in the pM-nM range, with easy routes for affinity maturation.
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From concept to in vitro validated proteins in 3-8 weeks.
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We know where our designs bind and can guide them to the epitopes you need, even when it involves PTMs.
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We can design for stability, expression, environment conditioning, specificity, and many more parameters.
# Support
# Publications
The first in vivo proof that de novo designed binders work as therapeutics: AI-designed proteins that neutralised lethal three-finger toxins and protected animals from an otherwise fatal venom challenge. A demonstration that designed binders can hit a hard, medically urgent target and function in a living system. (with the Baker lab)
Science 2025
Designed binders that recognise peptide–MHC complexes and direct immune cells to kill cancer cells, tackling one of the hardest and most valuable target classes in immunotherapy. Evidence the platform reaches targets conventional discovery struggles to address.
# Other sites
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